Pediatric and Neonatal Allergy and Immunology

Allergy symptoms commonly occur in children. Atopy is a tendency of exaggerated IgE antibody production and is defined by the presence of specific IgE in vivo or in vitro. Atopy represents a predisposition to atopic or allergic diseases including asthma, eczema, rhinitis and allergy. Scientific evidence of the systemic link between all of the atopic diseases has increased greatly. The atopy march starts early in life and it is widely believed that the fetal environment may be important for both the development of subsequent sensitization and disease manifestation. Early events under the influence of a spread of environmental factors, like exposure to environmental endotoxin, allergens, infections, and variations in nutrient intake, affect the expression of the atopy genotype. The age of onset of every atopic disease is different and may be influenced by the aforementioned factors. Typically, atopic eczema and allergy are commonly seen in young infants; while asthma usually starts after the age of three years, and rhinitis develops at a later stage in childhood.

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